Studies of genetic linkage between adult polycystic kidney disease and three markers on chromosome 16.
نویسندگان
چکیده
منابع مشابه
Studies of genetic linkage between adult polycystic kidney disease and three markers on chromosome 16.
Adult polycystic kidney disease (APKD) is a common genetic disorder that is inherited as an autosomal dominant trait. Recent reports show that, in some families, the APKD gene shows close genetic linkage to two chromosome 16 specific genetic markers. We have been conducting a genetic linkage study using 29 polymorphic isoenzyme and antigenic markers in 184 members of 12 APKD families. We presen...
متن کاملTwo genetic markers closely linked to adult polycystic kidney disease on chromosome 16.
The genetic locus for autosomal dominant adult polycystic kidney disease was recently assigned to chromosome 16 by the finding of genetic linkage to the alpha globin gene cluster. Further study showed that the phosphoglycolate phosphatase locus is also closely linked to both the locus for adult polycystic kidney disease and the alpha globin gene cluster. These findings have important implicatio...
متن کاملGenetic linkage study of family members of a patient with adult polycystic kidney disease.
OBJECTIVE: To study the feasibility of making an early diagnosis of adult polycystic kidney disease by using genetic linkage analysis in Hong Kong. DESIGN: Genetic linkage study. SETTING: University teaching hospital, Hong Kong. PARTICIPANTS: Six members of a Chinese family with a history of adult polycystic kidney disease. MAIN OUTCOME MEASURES: The inheritance pattern of adult polycystic kidn...
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15 صفحه اولEvidence for linkage disequilibrium between D16S94 and the adult onset polycystic kidney disease (PKD1) gene.
Genetic mapping of the PKD1 gene in chro-mosomal region 16pl3.3 has depended on the identification of closely linked markers and rare recombinants that suggest the order of loci in relation to meiotic crossover points.'2 This has led to the proposal that the PKD1 gene lies in an approximately 750 kb region close to marker loci D16S84, D16S125, and D16S94, and proximal to the hypervariable probe...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1987
ISSN: 1468-6244
DOI: 10.1136/jmg.24.8.457